血管生成拟态表达对食管鳞癌患者术后复发时间的影响

摘要

目的 探讨VM在食管鳞癌组织中表达情况以及对食管鳞癌患者术后复发时间的影响.方法 采取免疫组织化学方法检测VM在食管鳞癌组织的表达情况,计算微血管密度(MVD),根据VM是否表达将40例食管鳞癌患者分成VM阳性表达组和阴性表达组,分析其差异性,结合临床病理资料,采用Cox模型多因素分析食管鳞癌患者术后复发的影响因素.结果 将MVD以有无VM结构分组进行组间比较,差异有统计学意义(P<0.001);Cox多元回归分析显示:VM是否阳性(P=0.036)和淋巴结转移(P=0.040)为食管鳞癌患者术后复发的独立预后因素,与浸润深度(P=0.175)、VEGF是否阳性(P=0.750)等因素无关.结论 VM表达与食管鳞癌癌患者术后复发时间密切相关,是影响食管鳞癌患者术后生存期的独立危险因素.%Objective To investigate the expression of VM, and postoperative reappea time they affected on the patients of esophageal squamous cell carcinomas. Methods The two step envision immunohistochemical method was used in this experi-ment to detect the expression of VM in esophageal squamous cell carcinomas. MVD was calculated, Forty cases of esophageal squa-mous cell carcinomas were divided into two groups by expression of VM, analyzing the difference, postoperative reappear time of e-sophageal carcinoma was analyzed with multivariate Cox proportional hazards regression analyze combined their clinical date . Re-sults Statistic analysis showed that the MVD calculation had significantly different ( P<0. 001 ) between VM positive expression and VM negative expression, COX analysis demonstrated the lymph node metabasis(P=0. 036),positive or negative expression expression of VM(P=0. 040) were associated with the prognosis. but they had no relationship with depth of infiltration(P=0. 175)and positive or negative expression of VEGF(P=0. 750). Conclusion expression of VM WAS closely related with postoper-ative reappear time of esophageal carcinoma,was independent risk factor that affect postoperative reappear time of esophageal carci-noma.