Objective To investigate the safety and efficacy of thermotherapy combined with chemotherapy in the treat-ment of advanced ovarian cancer. Methods According to random table method,72 patients with advanced ovarian cancer were di-vided into study group(chemotherapy combined with thermotherapy)and control group(chemotherapy group),36 cases in each group. Patients in study group received TC regimen chemotherapy combined with thermotherapy,while patients in control group re-ceived TC regimen chemotherapy alone. The tumor size,therapeutic effect,changes of tumor marker CA125,incidence of adverse reactions,improvement of living quality and survival rates were compared between the two groups before and after treatment. Re-sults After treatment,the diameters of tumors in the study group were significantly smaller than those in the control group( P＜0. 05),and the rate of complete remission(CR)plus partial remission(PR)was 69. 44%(25/36),which was higher than 44. 44%(16/36)of the control group,the difference being statistically significant(P＜0. 05). CA125 of the two groups both acquired a de-crease after treatment and CA125 of the study group was lower than that of the control group(P＜0. 05). The incidence of adverse reactions such as leukopenia,gastrointestinal reaction,liver and kidney damage in the study group was lower than that in the control group,and the improvement of living quality as well as the cumulative survival rate of the study group were both better than those of the control group,with statistically significant difference( P＜0. 05). Conclusion Thermotherapy combined with chemotherapy can effectively improve the therapeutic effect of advanced ovarian cancer and prolong the survival time of patients. ,which is an ef-fective and safe therapy.%目的 探讨热疗联合化疗治疗晚期卵巢癌的安全性和有效性.方法 按随机表法将72例晚期卵巢癌患者分为研究组(化疗+热疗)及对照组(化疗),每组36例.研究组在接受TC方案化疗的基础上联合热疗,对照组单纯接受TC方案化疗.比较两组患者治疗前后肿瘤的大小,治疗效果,肿瘤标记物CA125变化,不良反应发生率,生活质量改善情况及生存情况.结果 治疗后研究组的肿瘤直径明显小于对照组(P ＜0. 05),完全缓解(CR) +部分缓解(PR)率为69. 44%(25/36),高于对照组的44. 44%(16/36),差异有统计学意义(P＜0. 05).治疗后两组CA125水平均下降,且研究组低于对照组(P＜0. 05).研究组白细胞下降、胃肠道反应、肝肾损害等不良反应发生率低于对照组,生活质量改善情况及累计生存率均优于对照组,差异有统计学意义(P＜0. 05).结论 热疗联合化疗可以有效提高晚期卵巢癌的治疗效果,延长患者生存期,是一种有效安全的治疗方法.
展开▼
