6～12岁双生子女童颅面软硬组织形态的遗传作用分析

摘要

Objective To study how genetic factors influencing morphology of soft and hard craniofacial tissue of twin girls aged 6 to 12.Methods The results of projection measurements for 183 twin girls born between January 2012 and May 2017 were analyzed.These girls were divided into Observation Group(MZ group,n=110 pairs of twins)which consisted of monozygotic twins and Control Group(DZ group,n=110 pairs of twins)which consisted of dizygotic twins.Relative indicators(L1 to L3,H1 to H3,G′G,SnA,G-SnPos and NsPrnPos)were compared between the two of each twins in the two groups.Results In MZ group, mean difference of L3,H1 to H3,G′G,G-SnPos and NsPrnPos between the two of each twins were significantly lower than DZ group,the difference being statistically significant(P<0.05).Mean difference of L3 in 7,10 and 11-year-old subgroups of MZ group were significantly lower than DZ group,mean difference of H1 in 9,10 and 12-year-old subgroups of MZ group were lower than DZ group,mean difference of H2 in 10,11 and 12-year-old subgroups of MZ group were lower than DZ group,mean difference of H3 in 10,11 and 12-year-old subgroups of MZ group were lower than DZ group,mean difference of G′G in 7,10,11 and 12-year-old subgroups of MZ group were lower than DZ group,mean difference of SnA in 9 and 10-year-old subgroups of MZ group were lower than DZ group,mean difference of G-SnPos in 9,10 and 12-year-old subgroups of MZ group were lower than DZ group, mean difference of NsPrnPos in 7,10,11 and 12-year-old subgroups of MZ group were lower than DZ group,the differences all be-ing statistically significant(P<0.05).Conclusion The depth of the lower part of the craniofacial region is related to environmen-tal factors,the height of the craniofacial region is influenced by genetic factors and the thickness of the soft tissue is influenced by environmental and genetic factors together.%目的 探讨遗传因素对6~12岁双生子女童颅面部软硬组织形态的影响.方法 分析2012年1月至2017年5月183对双生子女童的投影测量结果,按照卵型鉴定结果,分为观察组(MZ组,n=110对)为同卵双生子,对照组(DZ组,n=110对)为异卵双生子,分别比较两组受试者对间遗传作用相关指标(L1~L3、H1~H3、G′G、SnA、G-SnPos、NsPrn-Pos)平均差值.结果 MZ组对间L3、H1~H3、G′G、G-SnPos、NsPrnPos指标平均差值明显低于DZ组,差异均有统计学意义(P<0.05);7、10、11岁组MZ受试者L3平均差值明显低于DZ组,9、10、12岁组MZ受试者H1平均差值低于DZ组, 10、11、12岁组MZ受试者H2平均差值低于DZ组,10、11、12岁组MZ受试者H3平均差值低于DZ组,7、10、11、12岁组MZ受试者G′G平均差值低于DZ组,9、10岁组MZ受试者SNA平均差值低于DZ组,9、10、12岁组MZ受试者G-SnPos平均差值低于DZ组,7、10、11、12岁组MZ受试者NsPrnPos平均差值低于DZ组,差异均有统计学意义(P<0.05).结论 颅面部下部深度与环境因素有关,颅面部高度受遗传因素影响,软组织厚度受环境和遗传因素共同作用.