Objective To investigate the effect of natural progesterone on bone mineral density in early postmenopausal women .Methods After endometrial cancer surgery ,60 patients ,who were informed ,were di-vided into two groups according to endometrial carcinoma progesterone receptor positive or not .In the experimen-tal group ,30 patients took micronized progesterone 20 mg ,calcium 600 mg and vitamin D 125 U everyday for 6 months .In the control group ,30 patients took calcium 600 mg and vitamin D 125 U everyday for 6 months .Body mass index (BMI) ,blood urea nitrogen (BUN) ,creatinine (Cr) ,blood alanine aminotransferase (ALT ) ,blood triglycerides (TG) ,bone mineral density (BMD) and bone metabolism index alkaline phosphatase (ALP) in these patients were measured before and after the treatment of 3 months and 6 months respectively .Results BMI , BUN ,Cr and blood alanine aminotransferase (ALT) of experimental treatment group and control group were of no significant difference before and after the treatment(P>0 .05) .Compared to control group ,the TG of experimen-tal group was not statistically significant before the treatment ,3 months after the treatment and 6 months after the treatment(P>0 .05) .Compared to control group ,the heel BMD of experimental group was not statistically signifi-cant before and after the treatment(P>0 .05) .Compared to the time before treatment ,the heel BMD of experi-mental group and control group were not statistically significant after 3 months of treatment (P>0 .05) .The heel BMD of experimental group and control group were increased significantly after 6 months of treatment than 3 months of treatment .Before the treatment ,the ALP value of experimental group and control group was of no sig-nificant difference (P>0 .05) .After 3 months of treatment and 6 month of treatment ,the ALP values of experi-mental group and control group were both increased ,and the ALP value of experimental group was significantly higher than that of the control group (P<0 .05) .Conclusion Compared to taking calcium and vitamin D simply , taking calcium and vitamin D combined with micronized progesterone was more effective to promote bone forma-tion .But there was no significant difference in improving bone density between taking calcium and vitamin D sim-ply and taking calcium and vitamin D combined with micronized progesterone .%目的 探讨天然孕激素对绝经早期妇女骨密度的影响.方法 通过患者的知情同意 ,将60例子宫内膜癌术后患者按内膜癌组织孕激素受体阳性与否将其分为2组 :试验组30例 ,给予微粒化孕酮(20 m g/d )、钙剂(600 mg/d)及维生素D(125 U/d)治疗6个月 ,对照组30例 ,给予钙剂(600 mg/d)及维生素D(125 U/d)治疗6个月.观察2组治疗前、治疗3个月后及治疗6个月后体质量指数( BMI)、尿素氮(BUN)、肌酐(Cr)、血丙氨酸氨基转移酶(ALT)、血甘油三酯(TG)、骨密度值及骨代谢指标血清碱性磷酸酶(ALP)的变化.结果 试验组及对照组用药前后BMI、BUN、Cr及血ALT差异均无统计学意义(P>0 .05).试验组及对照组在治疗前、治疗3个月后及治疗6个月后TG差异均无统计学意义(P>0 .05) .在治疗前后试验组足跟部BMD与对照组相比 ,差异无统计学意义(P>0 .05).治疗3个月后 ,试验组及对照组足跟部BMD与治疗前相比 ,差异无统计学意义(P>0 .05).治疗6个月后 ,试验组及对照组足跟部BMD较治疗3个月后均显著升高(P<0 .05).在治疗前 ,试验组及对照组ALP值差异无统计学意义(P>0 .05).在治疗3个月及6个月后 ,试验组及对照组 ALP值均有升高 ,并且在治疗后试验组ALP值显著高于对照组(P<0 .05).结论 绝经早期孕酮联合维生素D及钙比单纯给予维生素D及钙在骨形成方面效果更好 ,而在改善骨密度方面效果不显著.
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