脓毒血症患者凝血功能紊乱与病情严重程度及预后的关系

摘要

Objective To explore the relationship between coagulation dysfunction and disease severity and prognosis of patients with sepsis .Methods We retrospectively analysed the data of 132 cases of patients with sep‐sis ,from January 2012 to June 2015. The APACHE Ⅱ score were compared between normal indexes and abnormal indexes of coagulation groups .Then the indexes of coagulation were compared between survival group and death group .Results The APACHEⅡ score showed that only in abrormal group ,PT and D‐dimer were significantly higher than the normal group( P < 0 .05) .In death group the PT ,APTT and D‐dimer increased significant and FIBdecreased significantly( P <0 .05) .Conclusion The PT and D‐dimer can be one of the indexes for predicting the prognosis of patients with sepsis .%目的：探讨脓毒血症患者凝血功能紊乱与病情严重程度及预后的关系。方法选取2012年1月至2015年6月入住北京世纪坛医院急诊病房及纤维蛋白原（EICU ）并确诊脓毒血症患者132例，分析凝血指标正常组及异常组患者急性生理和慢性健康状况评分Ⅱ（APACHEⅡ），并检测存活组及死亡组各项凝血指标。结果凝血酶原时间（PT）及D‐二聚体（D‐Dimer）异常组APACHEⅡ评分均明显高于正常组，差异有统计学意义（P＜0.05）。而活化部分凝血活酶时间（APTT）及纤维蛋白原（FIB）指标正常组与异常组APACHEⅡ评分差异无统计学意义（P＞0.05）。死亡组PT、APTT延长，FIB下降，D‐dimer增高，存活组与死亡组2组之间比较差异有统计学意义（P＜0.05）。结论脓毒血症患者凝血功能指标PT及D‐dimer对病情严重程度及预后的评估有指导意义。