前哨淋巴结阳性早期乳腺癌患者r非前哨淋巴结状态临床分析

摘要

Objective To investigate the correlation between clinicopathological features and axillary non-sentinel lymph node status in sentinel lymph node (SLN ) positive early breast cancer patients . Methods Fifty-two cases of breast cancer patients who underwent axillary lymph node dissection with positive sentinel lymph node biopsy (SLNB) in Shunyi Maternal and Children′s Hospital from January 1 ,2008 to December 31 ,2014 were ret-rospectively analyzed .The clinical stage of all patients was T 1-2N0M0 .Among them ,38 cases were non-SLN negative ,and 14 cases were non-SLN positive .Comparison of numeric variables between groups were performed using t test ,and Pearsonχ2 test or Fisher exact probability method was used for comparison of categorical variables between two groups.Results The rate of axillary non-SLN metastasis was 27％ ,age ,BMI ,menarche age ,meno-pause ,tumor size ,pathological type ,pathological grade ,hormone receptor status ,HER-2 expression ,number of axillary lymph nodes excision were all non-related to the status of non-SLN (all P>0 .05) .While the number of positive SLNs was significantly related to the status of non-SLN ( P <0 .05) .Conclusion With increase of the number of positive SLNs ,axillary non-SLN metastasis will subsequently increase .%目的 探讨前哨淋巴结阳性早期乳腺癌患者的临床病理特征与腋窝非前哨淋巴结转移状态的相关性.方法 回顾性分析顺义区妇幼保健院2008年1月至2014年12月收治的52例前哨淋巴结活检阳性后行腋窝淋巴结清扫的乳腺癌患者资料,临床分期为T1-2N0M0,其中非前哨淋巴结阴性者38例、非前哨淋巴结转移阳性者14例.组间数值变量的比较采用2个独立样本的t检验,分类变量采用2个独立样本的 χ2检验或Fisher精确概率法.结果 腋窝非前哨淋巴结转移率为27％,患者年龄、体质量指数(BMI)、初潮年龄、是否绝经、肿瘤大小、病理类型、病理分级、激素受体状态、H ER-2状态、清扫腋窝淋巴结个数与非前哨淋巴结状态无关,差异无统计学意义(均P>0.05),患者前哨淋巴结阳性个数与非前哨淋巴结状态有关,差异有统计学意义(P<0.05).结论 随着前哨淋巴结阳性个数的增加,腋窝非前哨淋巴结转移会增多.