针刺治疗功能性消化不良疗效观察及对血清胃促生长素影响

摘要

ObjectiveTo observe the clinical efficacy of acupuncture in treating functional dyspepsia due to liver stomach disharmony and its action mechanism.MethodSixty-eight patients were divided into an acupuncture group and a Western medication group by using the random number table, 34 cases in each group. The acupuncture group was intervened by acupuncture [majorly selecting Neiguan (PC6), Qimen (LR14), Zhongwan (CV12), Tianshu (ST25), Zusanli (ST36), Taichong (LR3), and Xingjian (LR2)], while the Western medication group was by using Domperidone tablets, both for 2 weeks. The syndrome score of traditional Chinese medicine (TCM), serum ghrelin content and clinical efficacy were observed before and after treatment for comparison and analysis.ResultThe total effective rate was 91.2% in the acupuncture group, significantly different from that in the Western medication group (P<0.05); after treatment, the TCM syndrome scores decreased significantly (P<0.05) and serum ghrelin contents increased significantly (P<0.05) in both groups; while the improvements were more significant in the acupuncture group (P<0.05).ConclusionAcupuncture is effective in treating functional dyspepsia due to liver stomach disharmony, and its action mechanism is possibly related to the increase of serum ghrelin.%目的：观察针刺治疗肝气犯胃型功能性消化不良的临床疗效及其作用机制。方法将68例患者按随机数字表法分为针刺组和西药组，每组34例。针刺组予针刺治疗(主要取穴为内关、期门、中脘、天枢、足三里、太冲、行间)，西药组予口服多潘立酮片治疗。两组疗程均为2星期。观察两组治疗前后的中医证候评分、血清胃促生长素(Ghrelin)含量及临床疗效，进行比较分析。结果针刺组总有效率为91.2%，与西药组比较差异有统计学意义(P＜0.05)；两组治疗后中医证候评分均下降(P＜0.05)，血清 Ghrelin 含量均升高(P＜0.05)；组间比较，针刺组改善更明显，差异有统计学意义(P＜0.05)。结论针刺治疗肝气犯胃型功能性消化不良疗效确切，其机制可能与血清Ghrelin含量升高有关。