Objective To explore the clinical curative effect and mechanism of acupuncture therapy on functional dyspepsia ( FD) of Hyperactive liver-qi attacking stomach syndrome. Methods 68 patients, according to random number table, were divided into acupuncture group and Western medicine group, with 34 cases in each group. Acupuncture group received acupuncture therapy (the main acupoints are Neiguan, Qimen, Zhongwan, Tianshu, Zusanli, Taichong, Xingjian) , the Western medicine group was given Domperidone tablets. The two groups were treated for two weeks. Compare and analyze the symptomatic scores of TCM, serum ghrelin levels and clinical curative effect before and after treatment. Results The effective rate was 91.18% in the acupuncture group, which is statistically significant compared with the Western medicine group (P<0.05) ; both groups'symptomatic scores of TCM were decreased and the levels of serum ghrelin were increased (P<0.05, P<0.01) , while the acupuncture group was better than that of the Western medicine group ( P<0.05) . Conclusion Acupuncture therapy is effective and safe for FD of Hyperactive liver‐qi attacking stomach syndrome, and its mechanism may be associated with elevated serum ghrelin levels.%目的：探讨针刺治疗肝气犯胃证功能性消化不良（FD）的临床疗效及其作用机制。方法将68例患者按随机数字表法分为针刺组和西药组，每组34例。针刺组予针刺治疗（主要取穴为内关、期门、中脘、天枢、足三里、太冲、行间），西药组予多潘立酮片治疗。两组疗程均为2周。观察治疗前后的中医症状积分、血清胃促生长素（Ghrelin）含量及临床疗效，进行比较分析。结果针刺组的总有效率为91.18%，与西药组比较，差异有统计学意义（P＜0.05）；治疗后2组的中医症状积分均下降，血清Ghrelin含量均升高（P＜0.05，P＜0.01），组间比较，针刺组改善更明显，差异有统计学意义（P＜0.05）。结论针刺治疗肝气犯胃证功能性消化不良疗效确切，其机制可能与血清Ghrelin含量升高有关。
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