中年亚健康人群血清生化指标研究

摘要

目的：了解中年亚健康人群的血清生化指标特点。方法：以筛选出的中年（35～55岁）亚健康人群为研究对象（203例,其中男性131例,女性72例）,以中年健康人群作为对照（40例,其中男性20例,女性20例）,检测其空腹血尿酸（UA）、血糖（GLU）、血脂及肝功能相关的丙氨酸氨基转移酶（ALT）、天门冬氨酸氨基转移酶（AST）等生化指标,并分析各生化指标的特点。结果：中年亚健康人群的UA、TC、TG、TC/HDL-C和LDL-C水平均显著高于健康对照组,且亚健康男性高于同年龄段的亚健康女性（P〈0.05）,HDL-C水平显著低于健康对照组,且亚健康男性低于同年龄段的亚健康女性（P〈0.05）;GLU水平均无显著性差异（P〉0.05）;亚健康男性的TG水平达1.86±0.94 mmol/L,明显高出正常血脂上限水平1.7 mmol/L,表现出边缘性升高;亚健康组与健康组的ALT、AST、ALT/AST等肝功能指标无显著性差异,但是亚健康男性的ALT、AST、ALT/AST和ALP显著高于亚健康女性;亚健康男性三个年龄段的UA水平均高于正常范围;随着年龄的增长,亚健康人群的TG及TC/HDL-C水平均有增高的趋势,HDL-C则呈下降的走势。结论：中年亚健康男性的血尿酸和血脂等生化指标表现出异常的趋势。%The purpose of this study was to detect characteristics of serum biochemical indexes in middle-aged sub-healthy people.203 middle-aged sub-healthy（131 of male and 72 of female） and 40 middle-aged healthy people（20 male and 20 female） participated in testing and analyzing serum biochemical indexes（serum uric acid-UA,blood lipid-TC,TG,HDL-C,LDL-C,glucose-GLU,ALT and AST）.It was found that UA,TC,TG,TC/HDL-C and LDL-C were higher in sub-healthy than in healthy people,and higher in male than in female sub-healthy（P〈0.05）.HDL-C was lower in sub-healthy than in healthy people,and lower in male than in female sub-healthy（P〈0.05）.But no differences were found in GLU in all participants（P〉0.05）.It was noticeable that TG in male sub-healthy reached 1.86±0.94mmol/L,which overstepped 1.7mmol/L of upper limit in normal and manifested borderline increasing.And also ALT,AST,ALT/AST and ALT in male sub-healthy were higer than in female sub-healthy.The male sub-healthy UA were also gone beyond normal levels.With the growth of age,TG and TC/HDL-C in sub-healthy went up,and HDL-C went down.It could be seen that serum uric acid and blood lipid in male sub-healthy showed abnormity.