目的 观察在肝癌根治术中植入5-氟尿嘧啶(5-Fu)缓释剂对原发性肝癌早期复发的影响.方法 将100例原发性肝癌行肝癌根治术患者随机分为两组各50例.观察组于术中完整切除肿瘤后于残肝断面及大网膜分别植入5-Fu缓释剂,对照组不植入.比较两组术前1d及术后1个月血清甲胎蛋白(AFP)水平及术后1年复发率.结果 两组术后AFP水平明显均低于术前,观察组明显低于对照组,P均＜0.01；观察组1年复发率明显低于对照组,P＜0.05.结论 肝癌根治术中局部植入5-Fu缓释剂可明显降低血清AFP水平,减少肝癌早期复发率.%Objective To investigate the effect of implanting slow-released 5-Fu during operation on early recurrence of patients with hepatocellular carcinoma. Methods One hundred patients with hepatocellular carcinoma undergoing hepatectomy were divided into two groups randomly. The observation group were implanted with slow-released 5-Fu on the liver sections and epiploon when the carcinomas were completely resected, while the patients in control group accepted hepatectomy alone. The serum level of alpha fetoprotein ( AFP) 1 day before, 1 month after the operation and the 1 -year recurrence rate were compared between two groups. Results The serum levels of AFP after the operation were significantly lower than that before the operation in both groups, and which in observation group was significantly lower than that in control group, both P <0.01. The 1-year recurrence rate was significant lower in observation group than that in control group, P < 0.05. Conclusions Implanting slow-released 5-flourouracil during hepatectomy can decrease the serum level of AFP and the early recurrence rate of hepatocellular carcinoma.
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