未足月胎膜早破产妇胎膜组织中 TLR2表达变化及意义

摘要

目的：观察未足月胎膜早破产妇胎膜组织中Toll样受体2（ TLR2）的表达变化，并探讨其意义。方法未足月胎膜早破产妇98例，产后根据病理检查结果，分为胎膜早破非炎症组（非炎症组，48例）、轻度亚临床绒毛膜羊膜炎组（轻度炎症组，17例）、中度亚临床绒毛膜羊膜炎组（中度炎症组，21例）以及重度亚临床绒毛膜羊膜炎组（重组炎症组，12例），采用免疫组化法检测各组胎膜中的TLR2。结果中、重度炎症组胎膜组织中TLR2表达高于非炎症组，且重度炎症组＞中度炎症组＞轻度炎症组（P均＜0．05）。结论未足月胎膜早破合并亚临床绒毛膜羊膜炎产妇胎膜组织中TLR2表达上调，与其发病有关。%Objective To observe the expression changes of toll-like receptor 2 ( TLR2) in fetal membranes of pa-tients with preterm premature rupture of membranes ( PPROM) and to investigate the significance .Methods Ninety-eight cases of PPROM women were enrolled .According to the pathological test results , they were divided into non-inflamed PPROM group (non-inflamed group, n=48), mild subclinical chorioamnionitis group (mild inflammation group, n=17), moderate subclinical chorioamnionitis group ( moderate inflammation group , n=21 ) and severe subclinical chorioamnionitis group (severe inflammation group, n=12) group.The expression of TLR2 in fetal membranes was determined by immuno-histochemistry in each group .Results The expression of TLR2 in the moderate and severe inflammation groups was higher than that of the non-inflamed group , severe inflammation group >moderate inflammation group >severe inflammation group (all P<0.05).Conclusions The expression of TLR2 is up-regulated in PPROM women with subclinical chorio-amnionitis, which is associated with its pathogenesis .