目的：观察子宫腺肌病（AM）患者子宫内膜组织中雌激素受体（ER）、孕激素受体（PR）、类固醇受体辅助活化因子3（SRC-3）的表达变化，探讨其临床意义。方法采用组织芯片技术及免疫组化法检测42例AM患者异位内膜组织（异位内膜组）和15例子宫肌瘤患者非瘤区子宫内膜组织（对照内膜组）的ER、PR、SRC-3。结果与对照内膜组比较，异位内膜组ER、PR表达降低，SRC-3表达升高，P均＜0．05；对照内膜组增殖期ER、PR、SRC-3表达均高于分泌期（P均＜0．05），异位内膜组增殖期、分泌期ER、PR、SRC-3表达无明显差异（P均＞0．05）；异位内膜组分泌期ER表达低于对照内膜组分泌期（P＜0．05）。异位内膜组ER与SRC-3表达呈负相关（r＝－0．693， P＜0．01）。结论 AM患者子宫内膜组织中ER、PR低表达、SRC-3高表达，三者可能与AM的发生、发展有关。%Objective To observe the expression changes of estrogen receptor (ER), progesterone receptor (PR) and steroid receptor coactivator-3 (SRC-3) in the endometrial tissues of patients with adenomyosis (AM) and to investigate their significance .Methods The expression of ER , PR and SRC-3 was detected by immunohistochemistry and tissue mi-croarray method in the ectopic endometria of 42 AM patients (EE group) and in the normal endometria of 15 patients with hysteromyoma ( NE group) .Results Compared with the NE group , the expression of ER and PR was decreased , and the expression of SRC-3 was increased in the EE group (all P<0.05).The expression of ER, PR and SRC-3 in the prolifera-tive phase of the NE group was higher than that in the secretory phase (all P<0.05).No statistically significant differences were found in ER, PR and SRC-3 of the EE group between the proliferative phase and secretory phase (all P>0.05).In the secretory phase, the ER expression of the EE group was lower than that in the NE group (P<0.05).There was a neg-ative correlation between ER and SRC-3 in the EE group (r=-0.693, P<0.01).Conclusions ER and PR is lowly ex-pressed and SRC-3 is highly expressed in the endometrial tissues of AM patients , and they may be related with the occur-rence and development of AM .
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