Objective To study the effects of different timing of radiotherapy on the clinical efficacy, immune function and prognosis of patients with limited-stage non-small-cell lung cancer ( NSCLC) by induction chemotherapy.Methods Ninety-six cases of limited-stage NSCLC who received combination therapy of NP chemotherapy and radiotherapy were se-lected.They were divided into 3 groups (A, B, C) randomly according to the different initial time of radiotherapy.Pa-tients in the groups A, B and C started to receive the radiotherapy after 0, 2 and 5 cycles of NP chemotherapy, respective-ly.The clinical efficacy, adverse reactions and immune function ( CD3 +, CD4 +, CD8 +and NK cell percentage) of the three groups were compared, and Kaplan-Meier was used to estimate the survival curve about prognosis of patients in the three groups.Results The total effective rates of groups A, B and C were 77.4%, 62.5%and 46.9%respectively, and significant difference was found between and among these three groups (all P<0.05).The adverse reaction rates of three groups also had significant difference (all P<0.05).The cell percentage of CD3+, CD4 +, CD8 +and NK in the three groups was significantly lower than that before treatment, and the most significant decline was found in the group A ( all P<0.05) .The difference of survival rate between groups A and B was not significant, but they were both higher than that of group C (all P<0.05).Conclusion As the prolonged time of radiation, the curative effect of patients with limited-stage NSCLC is decreased and the prognosis is poor, but its effect on immune function was relatively less.%目的：研究不同放疗时机对诱导化疗的局限型非小细胞肺癌（ NSCLC）患者的临床疗效、免疫功能及预后的影响。方法选取96例接受放疗与NP方案化疗联合治疗的局限型NSCLC患者，依据放疗时机选择的不同将其均分成A、B、C组，放疗分别开始于化疗0、2、5个周期后，比较3组临床疗效、不良反应以及免疫功能指标（ CD3＋、CD4＋、CD8＋和NK细胞百分比），并利用Kaplan-Meier法对3组预后的生存曲线进行分析。结果 A、B、C组治疗总有效率分别为77．4％、62．5％、46．9％，3组及各组间比较，P均＜0．05；3组及各组间不良反应发生率比较，P均＜0．05；3组CD3＋、CD4＋、CD8＋和NK细胞百分比均较治疗前降低，以A组为著（P均＜0．05）；A、B组累计生存率差异无统计学意义，但均高于C组（P均＜0．05）。结论随着放疗介入时间的延长，局限型NSCLC患者的疗效降低，预后更差，但是对免疫功能的影响相对变小。
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