Cyclin D1在急性白血病骨髓组织中的表达及临床意义

摘要

Objective: Discussion on Cyclin Dl in acute leukemia bone marrow tissues and its clinical sig-nificance. Methods: Immunohistochemical staining method, detection of acute leukemia group, control group Cyclin in bone marrow Dl expression. Results: Acute leukemia bone marrow tissue in Cyclin positive expression rate of Dl in comparison with the control group (P<0. 05) ,the difference was statistically significant, refractory relapsed pa-tients (8/13) Cyclin in bone marrow Dl expression than in untreated patients (9/29). Conclusion:Cyclin Dl and a-cute leutiemia occurrence , development and prognosis of relationship.%目的:探讨Cyclin D1在急性白血病 骨髓组织中的表达及临床意义.方法:应用免疫组化染色法,检测急性白血病组、对照组骨髓组织中Cyclin D1的表达情况.结果:急性白血病组骨髓组织中Cyclin D1阳性表达率与对照组比较,差异具有统计学意义(P＜0.05);复发难治患者(8/13)骨髓组织中Cyclin D1的表达高于初发未治患者(9/29).结论:Cyclin D1与急性白血病的发生、发展及预后存在一定关联.