Obj ective:To explore an appropriate constituent ratios of Diandao powder for acne,which has lower adverse side effects and preferable effectiveness simultaneously.Methods:After acne model of rabbit ear was been made, 32 rabbits were divided into four groups,each of them included 8 ones respectively.Group A was treated by the external application of original Diandao powder,of which the constituent ratio of Dahuang and sulfur was 1:1 .While group B was administrated by the modified constituent ratio which was 1:2 of Da-huang versus sulfur,And group C by 2:1 .Once a day,two successive weeks.As a controlled model one,group D accepted nothing interfering.The sum of comedos and seb-orrhea ,as well as side adverse effects were observed during and after practiced the procedure.Results:After experiment, a prominent decline of sum of comedos was seen concurrently among group A,B and C,and a significant difference was found between the three groups and group D.The amount of sebum excretion in 24 hours has decreased in group A,B and C,after treated begin 1week and 2 weeks ,compared with group D.Meanwhile,group B had the lowest excretion and the most amount of erythema and exfoliation of epidermis synchronously than other groups statistically.Conclusion:Increasing the constituent ratio of sulfur in Diandao powder(or decreasing the constituent ratio of Dahuang meantime)could decline the sebum excretion,but contribute to the side effects of cutaneo.On the contrary,decreasing the ratio of sulfur(or in-creasing the ratio of Dahuang meanwhile),can refrain side effects of skin,but not counteract the anti-acne effectiveness.%目的：：探寻一个治疗痤疮的不良反应少且疗效好的颠倒散的最佳组方比例。方法：兔耳痤疮造模成功后,将32只白兔分为A、B、C、D 组,每组8只。其中A组给予颠倒散原方(大黄与硫磺比例为=1∶1)外搽；B组予改良颠倒散(大黄与硫磺比例为=1∶2),C 组予大黄与硫磺比例为=2∶1的颠倒散外搽。1 d1次,连续2周。模型对照D组不接受任何处理。观察指标：治疗期间及治疗后观察粉刺数量、皮脂腺分泌量以及不良反应。结果：实验结束时, A、B、C三组的粉刺数量较治疗前均显著减少,且与模型对照 D 组比较,差异具有显著性。治疗1周和2周后,三组24h皮脂腺分泌量均较 D 组下降,而同时 B 组皮脂腺分泌总量最少,但发生红斑及表皮剥蚀的几率最高。结论：增加硫磺在颠倒散方中的比例(或降低大黄的比例)更能抑制皮脂的分泌,但不良反应相应增加；但降低硫磺的比例(或增加大黄的比例)可减少不良反应的发生,但不会降低其抗粉刺作用。
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