益气活血解毒方治疗慢性病毒性乙型肝炎肝纤维化的临床研究

摘要

目的：：探讨慢性病毒性乙型肝炎肝纤维化行自拟益气活血解毒方治疗临床效果,为临床选择治疗方式提供参考。方法：将慢性病毒性乙型肝炎肝纤维化患者,按照数字表法分为对照组与治疗组各40例。对照组采用基础治疗,治疗组在对照组基础上联合益气活血解毒化痰的中药治疗,对比两组患者治疗前后中医证候积分、血清肝纤维化指标、肝功能指标、超声影像学指标。结果：治疗后治疗组 LN、HA、Ⅳ-C 分别为113.44±16.55μg/L、172.28±23.35μg/L、143.33±18.84μg/L,均明显优于对照组,对比差异有统计学意义(t=7.994,P=0.002；t=14.214,P=0.000；t=10.514,P=0.000)；治疗后治疗组 Alb、TBil、ALT、AST 分别为43.94±5.61 g/L、12.28±2.27μmol/L、64.06±8.11 U/L、38.14±5.34 U/L,均优于对照组,对比差异有统计学意义(t=5.247,P=0.015；t=6.347,P=0.008；t=6.137,P=0.009；t=4.995,P=0.018)；治疗后治疗组中医证候积分为5.23±0.67,明显低于对照组,对比差异有统计学意义(t=6.664,P=0.007),治疗组与对照组门静脉直径、脾肿指数治疗前后组内对比差异有统计学意义(P<0.05)。结论：益气活血解毒方可有效改善慢性病毒性乙型肝炎肝纤维化患者纤维化进展及临床症状。%Objective:To investigate effectiveness of Yiqi Huoxue Jiedu decoction treatment for chronic vi-ral hepatitis B fibrosis patients,to provide a reference for clinical treatment.Methods:80 cases of hepatic fibrosis with chronic toxicity patients were selected,they were divided into control group and observation group,40 cases each.The control group was treated with basic treatment,observation group was treated with Yiqi Huoxue Jiedu decoction treatment on base of treatment of control group,two groups of patients before and after treatment symptom scores,ser-um liver fibrosis,liver function,ultrasound imaging targets were compared.Results:After treatment observation group’ s LN,HA,Ⅳ-C were 113.44 ± 16.55μg/L,172.28 ± 23.35μg/L,143.33 ± 18.84μg/L,significantly better than the control group,the difference was statistically significant(t= 7.994,P = 0.002;t= 14.214,P = 0.000;t= 10. 514,P=0.000);after treatment observation group's Alb,TBil,ALT,AST was 43.94 ± 5.61 g/L,12.28 ± 2. 27μmol/L,64.06 ± 8.11 U/L,38.14 ± 5.34 U/L,better than the control group,the difference was statistically significant(t= 5.247,P = 0.015;t= 6.347,P= 0.008;t = 6.137,P= 0.009 ;t= 4.995,P = 0.018);after treatment observation group's symptom score was 5.23 ± 0.67,significantly lower than the control group,the difference was statistically significant(t= 6.664,P= 0.007),in the observation group and the control group,portal vein diameter, splenic swelling index before and after treatment showed significant significance within group (P<0.05).Conclusion:Yiqi Huoxue Jiedu decoction treatment has significant clinical effect for chronic viral hepatitis B fibrosis patients,can significantly improve symptoms,worthy of clinical application.