延龄草提取物对小鼠镇静催眠作用的实验研究

摘要

目的：研究延龄草提取物对小鼠镇静催眠作用。方法：通过小鼠直接睡眠法、自主活动能力测定实验、与阈下剂量及阈上剂量的戊巴比妥钠协同睡眠等实验方法，确定延龄草提取物的镇静催眠作用。结果：延龄草提取物能减少小鼠自主活动能力和行为，增加由阈下剂量及阈上剂量戊巴比妥钠诱导的小鼠入睡百分率和睡眠时间。结论：延龄草提取物对小鼠有一定镇静催眠作用。%ABSTRCAT Objective:To study the effects of sedative and hypnotic of Trillium Tschonoskii Maxim Extract on mice .Methods :To detest the independent activities by the experiment of direct sleep ,and observe the sedative and hyp‐notic of Trillium Tschonoskii Maxim Extract on mice By the sleep time experiments of suprathreshold sodium ,sleeping mice numbers of subliminal sodium pentobarbital .Results :The results showed that Trillium Tschonoskii Maxim Extract significantly inhibited the locomotion activity of mice and showed synergic effect on pentobarbital‐induced sleeping by in‐creased numbers of mice falling asleep ,reduced the sleep latency and prolonged the sleeping time .Conclusion:Trillium Tschonoskii Maxim Extract has a function of sedative and hypnotic .