醒脑通络汤联合高压氧对改善颅脑重度损伤患者意识功能障碍的作用研究

摘要

Objective:To study the effect of Xingnao Tongluo decoction combined with hyperbaric oxygen therapy on conscious dysfunction in patients with severe craniocerebral injury.Methods:Severe injury patients as the research data of 74 cases were randomly divided into the control group and study group,the control group was given hyperbaric oxygen therapy,study group in the control group based on the therapy combined with Xingnao Tongluo decoction treatment,after a course of treatment,clinical evaluation the effect and comparative analysis,score statis-tics of two groups of patients awake time,prognosis of Glasgow(GOS),observed before and after treatment in two groups of serum myelin basic protein in patients with(MBP),neuron specific enolase(NSE)and S100 protein (S100-B)expression.Results:The total effective rate of the control group was 64.86%,the total effective rate of the study group was 78.38%,and the clinical efficacy of the study group was better than that of the control group(P<0.05).After treatment,the serum levels of MBP,NSE and S100-B in the study group were better than those in the control group,and the difference between the two groups was P<0.05.After treatment,the two groups im-proved compared with the treatment group,compared with P<0.05.The sober time of the patients in the study group was less than that of the control group,and the score of GOS was better than that of the control group(P<0. 05).Conclusion:Xingnao Tongluo decoction combined with hyperbaric oxygen therapy can effectively improve the severe traumatic brain injury patients with disturbance of consciousness,shorten the recovery time of patients,im-prove the prognosis of patients with quality,reduce serum markers expression of nerve injury.%目的:研究醒脑通络汤联合高压氧治疗对于改善颅脑重度损伤患者意识功能障碍的作用.方法:选取74例颅脑重度损伤患者作为研究资料,以随机法均分后,纳入对照组与研究组,对照组给予高压氧治疗,研究组于对照组疗法的基础上联合自拟醒脑通络汤治疗,治疗1疗程后,评估临床疗效并予以对比分析,统计两组患者清醒时间、格拉斯哥预后评分(GOS),观察治疗前、治疗1疗程后两组患者血清髓鞘碱性蛋白(MBP)、神经元特异性烯醇化酶(NSE)、S100蛋白(S100-B)表达水平的变化情况.结果:对照组总有效率为64.86%,研究组总有效率为78.38%,研究组临床疗效较对照组良好(P<0.05).治疗后研究组血清中MBP、NSE、S100-B表达水平较对照组良好,组间对比差异有统计学意义(P<0.05);治疗后两组较治疗前均有所改善,组内对比差异有统计学意义(P<0.05).研究组患者清醒时间少于对照组,GOS评分优于对照组(P<0.05).结论:醒脑通络汤联合高压氧治疗能够有效改善颅脑重度损伤患者的意识功能障碍,缩短患者苏醒时间,提高患者预后质量,降低血清神经损伤标志物的表达水平.