抑抗方对免疫因素所致不孕不育患者FS H、雌二醇、睾酮等表达水平的影响及妊娠结局观察

摘要

Objective:To observe the effect of Yikang decoction on the efficacy,pregnancy outcome and sex-ual hormone secretion of infertility patients caused by immune factors.Methods:82 cases of immune infertility pa-tients as the data in this study,all patients were divided into control group and observation group,the control group received routine treatment,the observation group was treated with self-made Yikang decoction in the treatment of two groups of clinical curative effect evaluation of treatment;after a period of treatment,two groups were observed before and after the treatment of sex hormone index:follicle stimulating hormone(FSH)and luteinizing hormone (LH),estradiol(E2),testosterone(T),prolactin(PRL)levels in all patients were followed up for 6 months for patients with successful pregnancy rate statistics.The follow-up period of successful pregnancy was extended to the end of pregnancy,successful delivery rate statistics.Results:In the control group,the total efficiency of 73.17%, the total efficiency of the observation group 95.12%,observation group was more ideal(P<0.05);after treatment in observation group,FSH,E2and T levels than the control group,the observation group P< 0.05;successful pregnancy rate was 80.49%,the successful delivery rate was 78.05%,the control group of successful pregnancy rate 53.66%,successful delivery rate was 43.90%,the observation group was more ideal(P<0.05).Conclusion:Yikang decoction has a definite effect on infertility caused by immune factors,and can improve the FSH,PRL and other sex hormones.Therefore,it can effectively improve the successful pregnancy rate and the successful delivery rate.%目的:观察抑抗方对于免疫因素所致不孕不育患者的疗效、妊娠结局以及对患者性激素分泌水平的影响.方法:选取82例免疫性不孕不育患者作为本次研究资料,将全部入选患者分别纳入对照组与观察组,对照组行常规治疗,观察组在于常规治疗的基础上加用自拟抑抗方治疗;治疗1疗程后评估两组临床疗效,观察两组治疗前、后性激素指标:卵泡生成激素(FS H)、黄体生成激素(L H)、雌二醇(E2)、睾酮(T)、催乳激素(PRL)表达水平的变化,全部患者随访6个月统计成功妊娠率,对于成功妊娠的患者随访期延长至妊娠结束,统计成功分娩率.结果:对照组总有效率73.17%,观察组总有效率95.12%,观察组更为理想(P<0.05);治疗后观察组FS H、E2、T 分泌水平优于对照组(P<0.05);观察组成功妊娠率80.49%、成功分娩率78.05%,对照组成功妊娠率53.66%、成功分娩率43.90%,观察组更为理想(P<0.05).结论:自拟抵抗方对于免疫因素所致不孕不育患者具有明确疗效,可改善患者FS H、PRL等性激素指标,因此能够有效提高成功妊娠率与成功分娩率.