丹红注射液对高血压病患者血管内皮功能、炎症指标及氨基末端脑钠肽前体的影响

摘要

Objective:To study the effect of Danhong injection on vascular endothelial function,inflammation index and N-terminal pro-brain natriuretic peptide in hypertensive patients.Methods:A retrospective analysis of clin-ical data of 146 patients with hypertension were randomly divided into control group and observation group,with 73 patients in each group.The control group was treated with amlodipine.The observation group was treated with Danhong injection on the basis of the control group.After two courses of treatment(one course of 14 days),the vas-cular endothelial function,inflammation index and amino terminal Brain natriuretic peptide levels.Results:The blood pressure control rate in observation group was significantly higher than that in control group(90.41% vs 75.34%,P<0.05).After treatment,the levels of nitric oxide(NO)and endothelin(ET)The difference between the observa-tion group and before treatment was statistically significant(P<0.05),and the observation group improved signifi-cantly better than the control group,the difference was statistically significant(P<0.05);after treatment,the two groups of high-sensitivity C-reactive protein,MMP-9 and NT-proBNP were significantly lower than those in the con-trol group(P<0.05),and the difference between the two groups was statistically significant,The difference was statistically significant(P<0.05).After treatment,the endothelium-dependent vasodilation(FMD)and the contrac-tile function(NMD)of vascular endothelial function index of the two groups were significantly lower than those be-fore treatment(P<0.05),and the observation group was significantly higher than the control group,the difference was statistically significant(P<0.05);during the treatment and observation period,no adverse reactions occurred in both groups,with no significant difference(P> 0.05).Conclusion:Danhong injection in the treatment of hyperten-sion has good vascular endothelial function,reduce inflammation and reduce the role of NT-proBNP,worthy of clini-cal application.%目的:研究丹红注射液对高血压病患者血管内皮功能、炎症指标及氨基末端脑钠肽前体的影响.方法:回顾分析146例高血压患者临床资料,将其随机分为对照组和观察组,各73例.对照组给予氨氯地平片治疗,观察组在对照组的基础上给予丹红注射液治疗,治疗两个疗程(1个疗程14 d)后,观察对比两组患者血管内皮功能、炎症指标及氨基末端脑钠肽前体水平.结果:观察组血压控制率90.41% 明显优于对照组75.34%,差异有统计学意义(P<0.05);治疗后两组患者一氧化氮水(N O)升高,内皮素(ET)降低,观察组与治疗前对比差异有统计学意义(P<0.05),且观察组改善明显优于对照组,差异有统计学意义(P<0.05);治疗后两组高敏C反应蛋白(hs-CRP)、基质金属蛋白酶-9(M M P-9)、氨基末端脑钠肽前体(N T-proBN P)降低,与治疗前对比差异有统计学意义(P<0.05),且观察组明显低于对照组,差异有统计学意义(P<0.05);治疗后两组血管内皮功能指标内皮依赖性舒张功能(FMD)明显升高,收缩功能(NMD)明显降低,与治疗前对比差异具有统计学意义(P<0.05),且观察组升高明显优于对照组,差异有统计学意义(P<0.05);在治疗和观察期间两组患者均未发生不良反应,差异无统计学意义(P>0.05).结论:丹红注射液治疗高血压,具有良好的改善血管内皮功能,减轻炎症反应,降低N T-proBN P的作用,值得临床应用.