2,6-二甲基苯甲酸的合成工艺研究

摘要

2,6-dimethyl benzoic acid was synthesized by the reaction of nitrilization and then hydrolysis from the starting material 2,6-dimethyl bromobenzene; and the optimized reaction condition was obtained.2,6-dimethylbenzonitrile was firstly hydrolyzed to 2,6-dimethylbenzamide in the basic condition with 100％ yield,the target acid was obtained by hydr-olysis of amide in acid condition,the optimization of hydrolysis of 2,6-di methylbenzoamide is:amide:65％ H2SO4 =1∶10 mL,the reaction temperature was 110 ℃ and the reaction time was 12 h,the yield was 85％.%以2,6-二甲基溴苯为原料,经氰基化,两步水解等反应合成了2,6-二甲基苯甲酸,并对氰基水解反应的工艺条件进行了优化.先将氰基在碱性条件下水解成酰胺,收率:100％；再在酸性条件下水解酰胺,得到最优的酰胺水解条件是:酰胺与65％硫酸的配比为1 g∶10 mL,水解温度110℃,水解时间12 h,收率达到:85％.