珍脑胶囊对NaNO2所致记忆巩固障碍小鼠学习记忆能力的影响

摘要

Objective To investigate the effects of Zhen Nao Capsules(ZN) on consolidated disturbance of memory in mice. Methods The memory deficits mice were induced by hypodermic injection of sodium nitrite(120mg·kg-1).Foraging maze and step-down tests were performed to evaluate the learning and memory of the deficits mice.Results ZN(2 000mg·kg-1 and 1 000 mg·kg-1) remarkably reduced the number of trials in labyrinth test and reduced the mistake times of step-down and prolonged step down latency in step-down tests. Conclusion It showed that ZN had a better improvement function on learning and memory in memory deficits mice.%目的 观察珍脑胶囊对亚硝酸钠(NaNO2)所致记忆巩固障碍小鼠学习记忆能力的影响.方法 采用皮下注射NaNO2制造记忆巩固障碍模型,通过迷宫试验和跳台试验,观察药物时模型小鼠学习记忆能力的影响.结果 珍脑胶囊可缩短迷宫试验中记忆巩固障碍小鼠的觅食时间;能够延长跳台试验中记忆巩固障碍小鼠的触电潜伏期,减少小鼠的错误次数.高、中剂量效果较好.结论 珍脑胶囊有改善学习记忆能力作用.