移植冻融第4日8-细胞胚胎至第3日内膜后的临床结局分析

摘要

目的 探讨为第3日胚胎准备的内膜移植第4日8-细胞胚胎后的临床结局.方法 观察性分析1190个第3日滞后胚胎.将延长培养后优选的176个第4日8-细胞胚胎作为研究组,以同期660个第3日8-细胞胚胎作对照组.比较两组胚胎移植的临床结局.结果 研究组的种植率(20.45％)、临床妊娠率(15.91％)和活胎分娩率(14.20％)低于对照组(30.45％、27.42％、20.91％:P=0.009、0.002、0.046),但流产率(4.55％)与对照组相似(3.33％)(P＞0.05).研究组的新生儿出生体质量[(3556±381)g]高于对照组[(3 311±570) g](P=0.012).结论 移植第4日8-细胞胚胎到为第3日胚胎准备的内膜可以作为滞后胚胎安全有效的备选方法.%Objective To determine the clinical outcomes when day 4 8-cell embryo is transferred into endometrium prepared for day 3 embryos.Methods This study performed a retrospective analysis of 1 190 retarded embryos by extended culture in vitro.Among them,176 day 4 8-cell embryos were chosen and transferred as study group,and 660 day 3 8-cell embryo were matched as control group.Pregnancy outcomes were compared between the two groups.Results Achieved successful implantation rates,clinical pregnancy rate and live birth rate in study group (20.45％,15.91％ and 14.20％) were lower than those in control group (30.45％,27.42％ and 20.91％;P=0.009,0.002,0.046).Miscarriage rate was similar to the control (3.33％) (P＞0.05),and mean birth weight of study group [(3 556±381) g] was higher than that in control group [(3 311 ±570) g,P=0.012].Conclusion Transferring day 4 8-cell frozen embryo into endometriurn prepared for day 3 embryos can be a new and safe alternative for patients with slow embryos.