塞替派及丝裂霉素C在翼状胬肉切除术中的应用

摘要

目的探讨塞替派和丝裂霉素C(MMC)防止术后翼状胬肉复发的疗效。方法将182例翼状胬肉随机分为塞替派组（158例169眼）和丝裂霉素C组（24例24眼）进行病例对照研究。塞替派（1∶2 000）的应用方法是术后第3天滴用，MMC（0.2g*L-1）应用的方法分别为术中应用及术后第3天滴用。结果塞替派组角膜创面上皮修复的速度明显比丝裂霉素C组快（P<0.001），塞替派组翼状胬肉的复发率（2.96％）低于MMC组（8.33％）。结论翼状胬肉切除术后滴用塞替派是一种预防胬肉复发安全、简便和有效的辅助措施，且对复发性病例也行之有效。%Objective　To probe the curative effect of thiotepa and mitomycin C for the prevention of the relapse of pterygium after its operation.Methods　One hundred and eighty-two cases with pterygium were randomly divided into two groups:one group of thiotepa(158 cases with 169 eyes)and the other group of mitomycin C (24 cases with 24 eyes) and a comparative study was conducted.Thiotepa was used through dropping on the third day after the operation(1∶2 000),while MMC was used in the same way during the operation and on the third day after the operation respectively(0.2g*L-1).Results　In the group of thiotepa,the wounded skin on the cornea was repaired significantly more rapidly than that in the group of mitomycin C,and the rate of the relapse of pterygium was lower in the former group than that in the latter one.Conclusion　Applying thiotepa by dropping after the excision of pterygium is a safe,simple and effective supplementary measure for the prevention of pterygium relapse and also effective for recurring cases.