Objective To analyze the correlation of the macular retinal ganglion cells-inner plexiform layer (GCIPL) thickness and the axial length and refractive power in myopia,thereby providing guidance for GCIPL thickness analysis in myopic glaucoma patients.Methods A total of 95 patients (190 eyes) with different degrees of myopia were recruited from October 2015 to September 2016 in Shenyang HE Eye Hospital,with age ranging from 18 to 36 years.Variables including gender,age,axial length,medical optometry diopter (spherical equivalent),GCIPL thickness (the mean,minimum,superior,inferior,temporal superior,temporal inferior,nasal inferior and nasal superior parameter) were recorded.According to diopter,all patients were divided into A group (-0.25 to-3.00D),Bgroup (-3.25 to-6.00 D),C group (＞-6.00 D);moreover,according to the axial length,they were assigned into A1 group (22 to 24 mm),B1group (＞24 to 26 mm) and C1 group (＞26 mm),and all above variables were compared.Single factor analysis of variance was used to analyze the differences in GCLIP thickness parameters between the 3 groups and Pearson correlation analysis was used to analyze the correlation of GCIPL thickness with different diopters and axial length.Results There was no significant difference in gender and age,but there were significant differences in the mean diopter and axial length among the 3 groups (F =523.963,P =0.000;F =57.452,P =0.000).And a negative correlation was presented between axis length and refractive power (r =-0.707,P =0.000) in all patients.There were significant differences in GCIPL thickness (the mean,minimum,superior,inferior,temporal superior,temporal inferior,nasal inferior and nasal superior parameter) among A,B and C group (F =3.231-16.500,all P ＜ 0.05) as well as among A1,B1 and C1 group (F =5.234-19.999,all P ＜ 0.05).The thickness of GCIPL was negatively correlated with refraction power (r =-0.419 to-0.153,all P ＜ 0.05),and the axial length(r =-0.407 to-0.241,all P ＜ 0.05).Conclusion With the increase of diopter and axial length,the thickness of GCLIP gets thinner in myopic patients.The effect of axial length should be taken into consideration when the GCLIP thickness of myopic glaucoma patients is evaluated.%目的 分析视网膜黄斑区神经节细胞-内丛状层(ganglion cell and inner plexiform layer,GCIPL)厚度与不同近视人群眼轴及屈光度的相关性,以期为合并近视青光眼人群GCIPL厚度分析提供指导.方法 选取2015年10月至2016年9月在我院就诊的18 ～36岁的不同程度近视患者95例(190眼).记录所有患者性别、年龄、眼轴、医学验光屈光度(等效球镜)、GCIPL的厚度,包括平均、最小、上方、下方、颞上、颞下、鼻上、鼻下共8个参数.根据屈光度分为A组(-0.25～-3.00 D)、B组(-3.25 ～-6.00 D)、C组(＞-6.00 D).根据眼轴长度分为A1组(22 ～ 24 mm)、B1组(＞24～26mm)、C1组(＞26 mm),进行所有参数的比较.各组的性别及年龄差异均无统计学意义(均为P＞0.05).但各组平均屈光度和眼轴长度差异均有统计学意义(F=523.963,P=0.000;F=57.452,P=0.000).采用SPSS 20.0软件单因素方差分析3组间GCLIP厚度参数的差异及Pearson相关性分析不同屈光度、眼轴长度与GCIPL厚度的相关性.结果 眼轴长度和屈光度之间呈显著负相关(r=-0.707,P =o.ooo).不同屈光度分组8个厚度参数之间差异均有统计学意义(F=3.231～16.500,均为P＜0.05).不同眼轴长度分组8个厚度参数之间差异均有统计学意义(F =5.234～ 19.999,均为P＜0.05).GCIPL厚度与屈光度均呈负相关(r=-0.419～-0.153,均为P＜0.05),与眼轴长度均呈负相关(r=-0.407 ～-0.241,均为P＜0.05),随着屈光度增大及眼轴增长,GCLIP 厚度逐渐变薄.结论 近视人群随着屈光度和眼轴的增长,GCLIP厚度也逐渐变薄.采用GCLIP厚度评估合并近视青光眼人群时要考虑眼轴长度的影响.
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