系统性红斑狼疮眼底病变评估和分型

摘要

目的 分析系统性红斑狼疮患者的眼底表现特征.方法 对27例(54眼)眼底有病变的系统性红斑狼疮患者行荧光素眼底血管造影检查并与眼底检查结合进行综合分析.对患者的系统性红斑狼疮活动性指数(systemic lupus erythematosus disease activity in-dex,SLEDAI)进行计算,并采用SPSS 19.0中的t检验进行统计分析.结果27例患者的眼底表现可以分为4种类型,即毛细血管阻塞型(14例28眼)、动脉阻塞型(6例11眼)、静脉阻塞型(6例7眼)和脉络膜血管阻塞型(1例2眼).24例患者进行了SLEDAI评分.5例动脉阻塞型患者的SLEDAI为(25.6±2.2)分,显著高于其他患者的SLEDAI评分(18.2±2.9)分(P＜0.05).结论 不同血管阻塞的分型有助于了解系统性红斑狼疮患者的眼底病变情况,并可能与疾病活动程度相关.动脉阻塞型的SLEDAI评分高于其他类型.%Objective To analyze the clinical characteristics of fundus changes in systemic lupus erythematosus (SLE) patients.Methods Color fundus and FFA were performed in 27 SLE patients (54 eyes) with fundus abnormalities.Clinical characteristics were analyzed.SLE disease activity index (SLEDAI) was evaluated in the patients.SLEDAI was analyzed by SPSS 19.0 Student-t test.Results Four clinical types were found in 27 patients.Capillary obstruction was found in 28 eyes of 14 patients,retinal artery occlusion in 11 eyes of 6 patients,retinal vein occlusion in 7 eyes of 6 patients,choroidal vessel obstruction in 2 eyes of 1 patient.SLEDAI was evaluated in 24 patients.SLEDAI in 5 patients with retinal artery occlusion was (25.6 ± 2.2) scores,which was significantly higher than other patients(18.2 ± 2.9)scores (P ＜0.05).Conclusion This clinical typing scheme may help to know fundus abnormalities in SLE patient,and it may be related to SLE activity.SLEDAI in patients with retinal artery occlusion is higher than other patients.