脂多糖的效应及其机理研究进展

摘要

脂多糖（lipopolysaccharide，LPS）是革兰阴性菌的主要成分，具有双重作用，适量的 LPS 可以激发机体的免疫反应，增强其免疫功能，而高浓度则会引起广泛而强烈的炎性反应。在 LPS 介导的信号转导通路中，有 LBP、CD14等多种双重作用的受体，与 LPS 的双重作用有关。论文对与 LPS 双重作用有关的受体以及LPS 的机理进行综述，以期为 LPS 的使用和 LPS 引起的炎症疾病的治疗提供参考。%Lipopolysaccharide (LPS)is the main component of Gram negative bacteria,which has double effects.Right amount of LPS can stimulate the body's immune system and enhance immune function,but, high concentrations of LPS can cause extensive inflammatory reaction strongly.In the signal transduction pathways mediated by LPS,there are a variety of double effect receptors,such as LBP and CD14 ,which may be associated with double effect of LPS.Here,the receptors of being related with LPS double effects and the mechanisms of LPS were reviewed,which provides the theory basis for preventing and treating the diseases caused by LPS.