目的:通过描述2010年北京市手足口病死亡病例的流行病学特点和临床特点,分析手足口病重症病例发生死亡的危险因素,为防制手足口病,减少手足口病的死亡提供科学依据.方法:采用现况描述及病例对照研究的方法,对2010年北京市手足口病死亡病例的特点进行分析.结果:2010年北京市共报告18例手足口病死亡病例,88.9％分布在5-8月份；死亡病例的男女比例为3.5∶1；年龄均小于4岁；流动人口聚集区的死亡病例较多；散居儿童及外地户籍儿童比例高,分别为83.3％和94.4％.死亡病例均出现出疹、发热及神经精神系统症状,整体精神状况,呼吸功能指标以及循环系统受累明显.与重症痊愈病例相比,感染EV71型病毒是发生死亡的危险因素(x2＝4.774,P=0.029).结论:手足口病死亡病例分布与重症病例分布基本一致.应对流动人口聚集地区的4岁以下婴幼儿重症病例进行重点防控.%Objective: To exmine the epidemiological and clinical characteristics of hand-foot-mouth disease deaths case in Beijing 2010, to explore the risk factors of intensive case development of deaths case, to provide the treasures data for preventing and control hand-foot-mouth disease deaths case. Methods: Use monitoring data of hand-foot-mouth disease deaths case and case-control study,was analyze the characteristic of deaths case. Results: There were 18 reportrd hand-foot-mouth disease deaths case in Beijing 2010. 88.9% deaths case was from May to August; male female ratio of deaths case was 3.5:1; age of patients was less than 4 years old for all of the case;most case were reported in floating of urban-rural population community;more deaths case were seen in scattered children and nonlocal census register children,and the rate was 83.3% and 94.4%. All of deaths case were suffered from rash, fever and mentally psychiatric symptoms;overall mental status, respiratory function, and circulatory system were clear indicated. Compared with intensive recovered case, the risk factors of deaths case was infected with EV71 type virus (x2=4.774,P=0.029). Conclusion: Distribution of HFMD deaths case were consistent with severe disease.Prevention and control strategies should focus on the children under 4 years, especially those live in floating population community.
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