泛素连接酶对Notch信号途径的调节作用

摘要

Notch signaling pathway is a conserved signaling pathway in the organic evolution process, and plays a decisive role in the orientation of cell growth and maturation. Notch signaling pathway is regulated strictly by a varirty of molecular mechanisms. In recent years, many studies have highlighted the importance of ubiquitination in the regulate of Notch signaling pathway. This paper summarized four types of E3 ubiquitin ligase Su(dx) / Itch, Sel-10, LNX, and Neuralized regarding regulate the Notch acceptor and Notch signal way ligand.%Notch信号途径是生物进化过程中高保守的信号通路,对细胞的定向发育及成熟起到决定性的作用.Notch信号途径受到多种分子机制的严格调控.近年来,多项研究均突出了泛素化在调控Noah信号途径活性中的重要性.本文就四种E3泛素连接酶Su(dx)/Itch、Sel-10、LNX以及Neuralized对于调控Noah受体及Notch信号途径配体的研究现况作一综述.