前体蛋白转化酶家族的重要成员之一:弗林蛋白酶

摘要

弗林蛋白酶(Furin)是前体蛋白转化酶家族的重要成员之一,广泛存在于各种组织和细胞系中.Furin经过两次自剪切去掉前肽后具有生理活性,能够识别特定的氨基酸序列并在TGN中对多种前体蛋白进行加工.Furin的作用底物不仅包括神经肽和肽类激素,还包括许多生长因子、受体、血浆蛋白酶、基质金属蛋白酶及细菌外毒素等,具有重要的生物学功能.%Furin is a key member of the family of proprotein convenases, which is expressed in all tissues and cell lines. It will gain its bioactivity after two self-cleavages and activate many other proproteins into their biologically active forms in the trans-Golgi network, because it can identify the specific aininu acid sequence. Furin possesses important biological functions as it is capable of cleaving precursors of a wide variety of proteins, not only neuropeptides and peptide hormones, but also many growth fectors,receptors, plasma proteases, matrix metalloproteinases and bacterial exotoxins.