白芍总苷对糜烂型口腔扁平苔藓外周血TNF-α,IFN-γ及IL-10水平的影响

摘要

目的:研究白芍总苷对糜烂型口腔扁平苔藓外周血肿瘤坏死因子(TNF-α)、γ-干扰素(IFN-γ)及白细胞介素-10(IL-10)水平的影响.方法:选取2014年7月至2015年7月我院接诊的糜烂型口腔扁平苔藓患者80例作为本次研究对象.对照组患者采用低浓度他克莫司治疗,观察组采用白芍总苷治疗,观察两组患者治疗前后血清TNF-α、IFN-γ及IL-10水平的变化、糜烂面积、疼痛评分及近期治疗疗效.结果:治疗后,观察组血清TNF-α、IL-10水平显著低于对照组,血清FN-γ水平明显高于对照组[(2.16±0.61)μg/mL vs(3.04± 0.80)μg/mL、(258.93± 5.72)ng/Lvs(273.41± 6.03)ng/L、(319.27± 53.46)ng/L vs(290.95±:51.03)ng/L(P＜0.05),糜烂面积、疼痛评分均显著低于对照组[(0.10± 0.03)cm2 vs(0.51± 0.10)cm2、(1.01±0.30)分vs(3.20± 0.78)分](P＜0.05),近期治疗疗效优于对照组95.00％(38/40)vs75.00％(30/40)(P＜0.05).结论:白芍总苷治疗糜烂型口腔扁平苔藓的效果显著,可能与其调节血清TNF-α、IFN-γ及IL-10的水平有关.%Objective:To study the effect of total glucosides ofpaeony on the serum tumor necrosis factor (TNF-α),Interferon-γ (IFN-γ) and interleukin-10 (IL-10) levels of patients with erosive oral lichen planus.Methods:80 patients of erosive oral lichen planus who were treated from March 2014 to March 2015 in our hospital were selected as the research objects.The control group was treated with Low concentration tacrolimus,while the observation group was treated with Total glucosides of paeony,Then the Changes ofIL-10,IFN-and TNF-α,erosion area,pain score before and after,the short-term therapeutic effect were compared.Results:After treatment,the serum TNF-α,IL-10 levels in the Observation group were lower than those of the control group,the seum IFN-γ level was higher than those of the control group[(2.16± 0.61)μg/mL vs(3.04± 0.80)μg/mL,(258.93± 5.72)ng/L vs(273.41± 6.03)ng/L,(319.27± 53.46)ng/L vs(290.95±51.03)ng/L(P＜0.05);the erosion area,pain score of the Observation group were less than those of the control group[(0.10±0.03)cm2 vs(0.51 ± 0.10)cm2,(1.01± 0.30)score vs(3.20± 0.78)score](P＜0.05),the short-term effective rate of observation group was statistically higher than that of the control group [95.00％(38/40)vs75.00％(30/40)(P＜0.05).Conclusion:Total glucosides of paeony was well for the erosive oral lichen planus,which could regulate the serum TNF-α,IFN-γ and IL-10 level and had im-munomodulatory effects.