盐酸小檗碱片联合四联疗法根治幽门螺杆菌的疗效观察

摘要

Tocomparetheclinicaleffectofberberinehydrochloridetabletscombinedquadruplechemotherapy for the eradication of helicobacter pylori( Hp),provide reference for the choice of treatment. Methods:A total of 160 patients with helicobacter pylori positive peptic ulcer disease were dvided into two groups . The group A :take orally esomeprazole (20 mg)+amoxicillin(1. 0 g)+colloidal bismuth subcitrate(220 mg)+ clarithromycin(0. 5 g),2 times per day,for ten days. The group B:take orally esomeprazole(20 mg)+colloidal bismuth subcitrate(220 mg)+amoxicillin(1. 0 g)+clarithro-mycin(0. 5 g),2 times per day,+berberine hydrochloride tablets(300 mg),3 times per day,for ten days. To observe and re-cord the eradication and adverse reactions of Hp. Results:The total eradication rate of HP of the group A were 81. 23%. The total eradication rate of HP of the group B were 87. 50%,siginificantly higher than the group A,the difference was statistically siginifiant(P﹤0. 05). The incidence adverse reactions of group B and group A were simler. The difference was not statistically siginificant(P﹥0. 05). Conclusion:Bismuth agent four transmitte adverse reactions did not significantly increased,the eradica-tion rate is higher,is the ideal reatment.%目的：对比盐酸小檗碱片联合四联疗法和四联疗法根除幽门螺杆菌（ Hp）方案的临床效果，为临床治疗方案的选择提供参考。方法：将160例幽门螺杆菌阳性消化性溃疡患者随机分为两组。A组：口服埃索美拉唑（20 mg）＋阿莫西林（1.0 g）＋枸橼酸铋钾（220 mg）＋克拉霉素（0.5 g），每日2次，服用10 d。B组：口服埃索美拉唑（20 mg）＋枸橼酸铋钾（220mg）＋阿莫西林（1.0g）＋克拉霉素（0.5g），每日2次，盐酸小檗碱片300mg，每日3次，服用10 d。观察记录Hp根除情况及不良反应。结果：两组Hp根除率分别为81.23%和87.50%，差异有统计学意义（ P﹤0.05）。两组不良反应率比较，差异无统计学意义（ P﹤0.05）。结论：盐酸小檗碱片联合铋剂四联组不良反应未明显增加，根除率更高，是较理想的治疗方案。