血清降钙素原、C反应蛋白及血白细胞计数联合检测在颅脑手术后颅内感染中的预测价值

摘要

Objective To study the diagnostic value of joint detection of procalcitonin (PCT), C-reactive protein (CRP) and white blood cell (WBC) in intracranial infection after craniocerebral surgery.Methods A total of 118 cases of craniocerebral surgery admitted from April 2015 to May 2018 in our hospital were divided into two groups:infection group (53 cases) and non-infection group (65 cases).The levels of PCT, CRP and WBC in both groups were detected and compared.The predicts value of intracranial infection was evaluated by the area under ROC curve, and the sensitivity and specificity of serum PCT, CRP and blood WBC were evaluated.Results After operation, the levels of PCT, CRP and WBC in the infection group were significantly higher than those in the non infected group.The difference between the two groups was statistically significant (P＜0.05).The working characteristic curve (ROC) analysis showed that the predicts value of PCT, CRP and WBC combined detection was higher than any index.Conclusions The combined detection of PCT, CRP and WBC has the highest sensitivity and specificity in predicting intracranial infection after craniocerebral surgery, and has high diagnostic value.%目的 探讨降钙素原(PCT)、C反应蛋白(CRP)、白细胞计数(WBC)联合检测在颅脑手术后颅内感染中的诊断价值.方法 将我院收治的颅脑手术患者118例作为研究对象,按照术后是否出现感染将其分为感染组(53例)和未感染组(65例),检测比较两组患者血清PCT、CRP及WBC水平,通过ROC曲线下面积对患者颅内感染预测价值进行评价,并评价PCT、CRP及WBC的灵敏度及特异度.结果 术后,感染组患者的PCT、CRP及WBC水平显著高于未感染组,两组差异有统计学意义(P＜0.05);经ROC曲线分析表明,PCT、CRP、WBC联合检测预测效能高于任一指标单独检测.结论 PCT、CRP及WBC联合检测预测颅脑手术后颅内感染的灵敏度及特异度最高,具有较高的诊断价值.