Objective To investigate the clinical effect of salt from salvia miltiorrhiza on patients with acute cerebral ischemia. Methods 96 patients with acute cerebral ischemia were randomly divided into 3 groups, group 1 ( n = 32, miltiorrhiza 100 mg/d ), group 2( n = 32, miltiorrhiza 200 mg/d ) and control group( n = 32 ). All the groups were treated with routine treatment of antiplatelet, brain protestant, brain circulation improvement and blood pressure control. The treatment lasted for 14 d. Before and 14 d after treatment, the neurologic impairment analysis, activity of daily living scale( ADL )were checked. Results After treatment, the NDS of group 1, group 2 and control group decreased from ( 21. 65 ±3.75),( 21.28 ±4.08 ),( 21.50 ± 3. 66 ) to ( 17.75 ±2.74 ),( 15.43 ±3.057 ),( 18.53 ± 3. 63 ) respectively( P <0. 05 ),in which,the improvement of group 2 was better than that of control group( P <0. 05 ); the ADL of group 1,group 2 and control group increased from ( 24. 21 ±3. 12 ),( 28. 25 ±4. 82 ),( 29. 53 ±4. 51 ) to ( 58. 23 ±5. 31 ),( 59. 23 ±8. 54 ),( 55. 78 ±8. 55 ) respectively( P <0. 05 ),and the increase of group 2 was more significant than that of control group( P < 0. 05 ). There was significant difference in total effective rate between group 2 and control group( 90. 62% vs. 68. 75% , P < 0. 05 ). Conclusion Mid-dose of salt from salvia miltiorrhiza can improve the symptom of patients with acute cerebral ischemia.%目的 探讨丹参多酚酸盐治疗急性脑缺血患者的临床疗效.方法 将96例急性脑缺血患者随机分为治疗1组、治疗2组、对照组,各32例,对照组采用常规治疗:抗血小板、脑保护剂及改善脑循环、血压控制等;治疗1组在常规治疗的基础上加用丹参多酚酸盐100 mg/d静脉滴注,共治疗14 d;治疗2组在常规治疗的基础上加用丹参多酚酸盐200 mg/d静脉滴注,共治疗14 d.测定治疗前后三组患者的神经功能缺失评分(NDS)和日常生活活动能力评分(ADL).结果 治疗1组治疗前后NDS为(21.65±3.75)、(17.75±2.74)分,治疗2组为(21.28±4.08)、(15.43±3.057)分,对照组为(21.50±3.66)、(18.53±3.63)分,三组NDS均降低(P<0.05),且治疗2组改善情况优于对照组(P<0.05).治疗1组治疗前后ADL评分分别为(24.21±3.12)、(58.23±5.31)分,治疗2组为(28.25±4.82)、(59.23±8.54)分,对照组为(29.53±4.51)、(55.78±8.55)分.三组治疗后ADL评分明显升高,但治疗2组较对照组升高明显(P<0.05).治疗2组总有效率(90.62%)高于对照组(68.75%)(P<0.05).结论 中剂量丹参多酚酸盐可显著改善急性脑缺血患者的病情,值得临床推广.
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