Objective To investigate the effect of recombinant human brain natriuretic peptide on BNP and renal function in elderly patients with acute decompensated heart failure (ADHF),and observe the clinical efficacy.Methods Totally 96 patients diagnosed with ADHF disease in our hospital from January 2015 to June 2016 were retrospectively analyzed and randomly divided into control group (n =48) and observation group (n =48) using random number table method.Patients in control group were treated with conventional anti-heart failure therapy,and patients in observation group were treated with recombinant human brain natduretic peptide (BNP) on the basis of routine treatment.After 2 weeks of treatment,the BNP and renal function were compared between the two groups before and after treatment,and the clinical efficacy of brain natriuretic peptide on patients was observed by evaluating the cardiac function.Results After treatment,the effective rate of heart function,24 h urine volume and left ventricular ejection fraction (LVEF) in observation group were higher than those of control group (P ＜ 0.05),while the serum creatinine,urea nitrogen and BNP were lower (P ＜ 0.05).Conclusion Recombinant human brain natriuretic peptide based on the conventional treatment in the treatment of ADHF can effectively improve the renal and cardiac function.%目的 探讨重组人脑利钠肽辅助对老年急性失代偿性心力衰竭(ADHF)患者BNP和肾脏功能的影响并观察临床疗效.方法 回顾性分析2015年1月至2016年6月我院心血管内科收治的96例临床确诊的ADHF患者,按随机数字表法分为观察组和对照组,每组48例.对照组患者仅采用常规抗心力衰竭治疗,观察组患者在常规治疗基础上,辅助应用重组人脑利钠肽.连续治疗2周后,比较两组患者治疗前后BNP和肾功能变化,通过心功能指标评估人脑利钠肽的临床疗效.结果 治疗后,观察组总体心功能改善有效率、24 h尿量和左心室射血分数(LVEF)高于对照组,血清肌酐、尿素氮、BNP水平低于对照组,差异均有统计学意义(P＜0.05).结论 在常规抗心衰治疗基础上辅助应用重组人脑利钠肽治疗ADHF,可有效改善心功能、肾功能.
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