SALL4基因在人恶性肿瘤中的研究进展

摘要

Malignant tumor is a serious threat to human health and its pathogenesis is complex , which caused by interaction of a variety of carcinogenic factors in the human body .SALL4 gene is a kind of newly dis-covered gene and it plays an important role in function of embryonic stem cell due to its protein transcription fac -tor with C2H2 zinc finger domain.Studies found that this gene mutation often results in occurrence of malignant tumor.This paper will summarize the molecular mechanism of SALL 4 in the occurrence and development of malig-nant tumor and its diagnosis and treatment on malignant tumor .%恶性肿瘤是当今严重威胁人类健康的一类疾病，其发病机制复杂，由人体中各种致癌因子相互作用引起。人类婆罗双树样基因（SALL4）是一种新发现的基因，因具有C2H2锌指结构的蛋白转录因子，在胚胎干细胞功能方面起重要作用。研究发现，该基因突变常导致恶性肿瘤的发生。本文就SALL4在恶性肿瘤发生发展中的分子机制及其对恶性肿瘤的诊断与治疗的作用等方面进行综述。