Development of microfluidic devices for islet transplantation and islet physiologys

摘要

This review discusses several microfluidic devices developed at the University of Illinois at Chicago(UIC) used for studying the physiology and pathophysiology of human islets and their applications in the human islet transplantation process. The review first introduces key issues found in the field of pancreatic islet transplantation as a clinical therapy for Type I diabetes. It then reviews microfluidic technologies that can be used to address those key issues, the unique features associated with each microfluidic device, and the application of each. Additionally, the review also briefly discusses the design and fabrication principles of UIC microfluidic devices.%本文讨论了芝加哥伊利诺伊大学研发的几种用于人胰岛生理和病理生理学研究的微流体装置及其在人胰岛移植中的应用。首先介绍了作为1型糖尿病临床治疗的胰岛移植领域关键问题。随后，回顾了可以解决这些关键问题的微流体装置、每一种微流体装置的独特之处及他们的应用。此外，本文也简单地讨论了芝加哥伊利诺伊大学这几种微流体装置的设计和制造原理。