射频消融联合经肝动脉栓塞化疗对肝癌术后复发患者生存率的影响

摘要

目的 探讨射频消融(radiofrequency ablation,RFA)+经肝动脉栓塞化疗(transarterial chemoem-bolization,TACE)联合治疗较单纯RFA或单纯TACE对肝癌术后复发患者预后生存率的影响. 方法 原发性肝癌术后有肝内复发而无肝外转移病例83例,按临床给予的治疗方案分为RFA组(A组),TACE组(B组),RFA+TACE联合组(C组),观察各组生存差异.结果 C组中位生存时间最长,(24.0±4.93)个月,B组次之,A组最短.累积生存率曲线显示C组生存率最高.A、B、C三组的0.5、1年生存率差异无统计学意义(P>0.05);2年生存率差异有统计学意义(P=0.041,P=0.030,均<0.05). 结论 RFA+TACE联合治疗较单纯RFA或TACE可以增加肝癌复发患者的2年生存时间,对肝癌术后复发患者是较好的选择.%Objective To dissuss the outcomes of hepatocellular carcinoma (HCC) recurrence patients′survival through treatment of RFA+TACE compared with RFA or TACE alone. Methods The 83 recurrented patients with hepatocellular carcinoma were collected and divided according to clinical treatment regimes into A (RFA) group,B(TACE) group,C(RFA+TACE) group;survival difference was observed for each group. Results Group C had the longest median survival time,24.0 ±4.93 months,followed by group B,finally was group A. Cumulative survival curve showed the highest survival rate in Group C. The three groups of A,B,C 0.5-year,1-year survival rates had no statistically significant difference (P>0.05);the 2-year survival rate had significantly higher in group C than in group A,B,with a significant difference (P<0.05). Conclusion RFA+TACE combined therapy can increase the survival time of recurrented patients with HCC compared with RFA or TACE alone.