Objective To observe the efficacy and adverse drug effect of Ziprasidone, an antipsychotics for methamphetamine-induced psychotic disorder. Methods Eighty patients with methamphetamine-induced psychiatric disorder were randomly divided into Ziprasidone group (n = 40, MD≤160 mg/d) and Risperidone group (n = 40, MD≤6 mg/d). Both groups were treated with Ziprasidone or Risperidone for 3 weeks. The efficacy was assessed with Brief Psychiatric Rating Scale ( BPRS) , and adverse drug effect with Treatment Emergent Symptoms Scale (TESS). Results The effective rates of ziprasidone group and Risperidone group were 92. 30% and 90. 00% respectively { NS, P > 0.05). Compared with Risperidone, Ziprasidone caused less weight gain and endocrine change (P < 0. 05). Conclusions Both Ziprasidone and Risperidone are effective in the treatment of methamphetamine-induced psychiatric disorder. The adverse effect of Ziprasidone is slighter.%目的 观察抗精神病药物齐拉西酮治疗甲基苯丙胺所致精神障碍的疗效及不良反应.方法 80例甲基苯丙胺所致精神障碍患者按随机数字表法分为齐拉西酮组和利培酮组各40例,分别用齐拉西酮(最大剂量≤160 mg/d)和利培酮(最大剂量≤6 mg/d)治疗21天.采用简明精神病量表(BPRS)和副反应量表(TESS)评定患者的精神病性症状、疗效和不良反应.结果 总有效率齐拉西酮组为92.50％,利培酮组为90.00％,两组比较差异无统计学意义(P＞0.05)；齐拉西酮组与利培酮组比较,体重增加较少,内分泌改变较少,差异有统计学意义(P＜0.05)；其他不良反应,两组差异无统计学意义(P＞0.05).结论 齐拉西酮与利培酮疗效相当,不良反应较轻.
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