Systemic sclerosis (SSc) is and connective tissue disease characterized by fibrosis of skin and internal organs. Localized scleroderma only involve skin. The pathogenesis of thess diseases is not clear. Though new therapeutic methods keep coming out and adopted,no specific treatment is identified. Treatments and advances in therapeutic study of localized scleroderma and systemic sclerosis are reviewed in this paper.%硬皮病是一种以皮肤及各系统胶原纤维硬化为特征的结缔组织疾病,病因未明.根据疾病累及的范围可分为局限性硬皮病(localized scleroderma)和系统性硬皮病(systemic sclerosis,SSc).虽然目前尚缺乏特效疗法,但治疗手段在不断增加.本文将对目前的治疗方法及相关进展进行综述.
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