术前使用帕瑞昔布钠提高腹腔镜胆囊切除术患者的术后恢复质量

摘要

目的 评定术前使用帕瑞昔布钠能否能提高接受腹腔镜胆囊切除术患者术后恢复质量.方法 选择2014年12月至2015年6月全身麻醉下择期行腹腔镜胆囊切除术的患者165例,采用计算机随机双盲对照分组法分为帕瑞昔布钠组(83例)和对照组(82例),分别给予帕瑞昔布钠40 mg(4 ml)或生理盐水4ml术前30分钟以上静脉注射.比较两组手术前及术后第一天恢复质量评分系统(QoR-40)评分,包括情绪、身体状态、心理状态、独立生活能力和疼痛五个单项评分及各项总分.结果 帕瑞昔布钠组术后第一天QoR-40总分高于对照组(P＜0.05),单项评分中,情绪评分、身体状态评分和独立生活能力评分均高于对照组(均P＜ 0.05),两组间术后心理状态评分及疼痛评分比较,差异无统计学意义(P＞0.05).结论 腹腔镜胆囊切除术的患者,术前使用帕瑞昔布钠能够提高其术后第一天的恢复质量,具体体现在情绪、身体状态和独立生活能力三个方面.%Objective To examine the effect of parecoxib on quality of recovery on the first day after laparoscopic cholecystectomy.Methods One hundred sixty-five patients undergoing selective laparoscopic cholecystectomy were randomized to receive either 40 mg/4 ml of parecoxib (parecoxib group) or 4 ml of placebo-saline (control group).A 40-item quality-of-recovery scoring system (QoR-40) was used preoperatively and on the first day postoperatively to all subjects.Results Global QoR-40 scores on the first day postoperatively were higher in the parecoxib group than that in the control group (P ＜ 0.05).Postoperative QoR-40 scores in the dimensions of emotional state,physical comfort and.physical independence were all improved in the parecoxib group when compared to the control group (P ＜ 0.05).Conclusion For patients undergoing selective laparoscopic cholecystectomy,the use of preoperative parecoxib could enhance the quality of recovery on the first day postoperatively.