复方丹芪注射液治疗气虚血瘀型冠心病心绞痛的临床疗效及安全性分析

摘要

Objective To analyze the clinical effect and safety of compound danqi injection on angina pectoris with qi-deficiency and blood-stasis type of TCM in patients with coronary heart disease.Methods From March 2013 to January 2014, a total of 146 coronary heart disease patients with angina pectoris were selected, all of them were diagnosed as qi -deficiency and blood-stasis type of TCM, and they were randomly divided into treatment group and control group, each of 73 cases.Based on conventional treatment, patients of treatment group were given compound danqi injection, while patients of control group were given danshen injection, both groups treated for 2 weeks as a course.Improvement of angina pectoris symptom and improvement of ECG after treatment, hemodynamic index before and after treatment and incidence of adverse reactions during treatment were compared between the two groups.Results Improvement of angina pectoris symptom and improvement of ECG of treatment group were statistically significantly better than those of control group (u=2.509, 2.308, P<0.05).No statistically significant differences of whole high blood viscosity, whole low blood viscosity, plasma viscosity, hematocrit or fibrinogen was found between the two groups before treatment (P>0.05); while above index of treatment group were statistically significantly lower than those of control group (P<0.05).During treatment, one case of treatment group occurred dizziness, 2 cases of control group occurred abdominal distension.Before and after treatment, routine blood, stool and urine examination results, liver and kidney function indicators of all of the patients were normal.Conclusion Compound danqi injection has certain clinical effect on angina pectoris with qi-deficiency and blood-stasis type of TCM in patients with coronary heart disease, which can effectively relieve angina pectoris symptom and improve hemorheology, with high safety.%目的：分析复方丹芪注射液治疗气虚血瘀型冠心病心绞痛的临床疗效及安全性。方法选取2013年3月—2014年1月莒南县人民医院心血管内科病房诊治的冠心病心绞痛患者146例，均符合“气虚血瘀型冠心病心绞痛”诊断标准，将患者随机分为治疗组和对照组，各73例。在常规治疗基础上，治疗组患者给予复方丹芪注射液，对照组患者给予丹参注射液，两组患者均以两周为1个疗程。比较两组患者治疗后心绞痛症状和心电图改善情况、治疗前后血流动力学指标及治疗期间不良反应发生情况。结果治疗后治疗组患者心绞痛症状改善情况和心电图改善情况优于对照组（ u值分别为2.509、2.308， P＜0.05）。治疗前两组患者全血高切黏度、全血低切黏度、血浆比黏度、红细胞比容及纤维蛋白原比较，差异均无统计学意义（ P＞0.05）；治疗后治疗组患者上述指标均低于对照组（ P＜0.05）。治疗组有1例患者出现头晕，对照组有2例患者出现腹胀。所有患者治疗前后血尿便常规及肝肾功能指标均在参考范围。结论复方丹芪注射液治疗气虚血瘀型冠心病心绞痛的临床疗效确切，能有效改善患者心绞痛症状和血液流变学，且安全性高。