冬病夏治穴位贴敷疗法对支气管哮喘缓解期患儿免疫细胞因子及肺功能的影响

摘要

Objective To explore the impact of winter diseases treated with acupoints sticking therapy in summer on immune cytokines and pulmonary function of children with bronchial asthma at remittent stage. Methods From July 2014 to August 2015,a total of 107 children with bronchial asthma at remittent stage were prospectively selected in the Department of Pediatrics,the Affiliated Hospital of Inner Mongolia Medical University,and they were divided into control group(n = 53)and treatment group(n = 54)according to the envelope method. Children of the two groups received acupoints sticking therapy for 10 times in canicular days of summer,thereinto children of control group received placebo acupoints sticking therapy,while children of treatment group received winter diseases treated with acupoints sticking therapy in summer. Immune cytokines( including NF-κB,IL-4,IL-6,IL-8,IL-10 and IL-13) and index of pulmonary function( including FEV1 and PEF) before and after treatment were compared between the two groups. Results No statistically significant differences of serum level of NF-κB,IL-4,IL-6,IL-8,IL-10 or IL-13 was found between the two groups before treatment(P ﹥ 0. 05);after treatment,serum levels of NF-κB,IL-4,IL-6,IL-8 and IL-13 of treatment group were statistically significantly lower than those of control group,while serum IL-10 level of treatment group was statistically significantly higher than that of control group(P ﹤ 0. 05). No statistically significant differences of FEV1 or PEF was found between the two groups before treatment(P ﹥ 0. 05),while FEV1 and PEF of treatment group were statistically significantly higher than those of control group after treatment( P ﹤ 0. 05). Conclusion Winter diseases treated with acupoints sticking therapy in summer can effectively adjust the immune cytokines and improve the pulmonary function of children with bronchial asthma at remittent stage.%目的：探讨冬病夏治穴位贴敷疗法对支气管哮喘缓解期患儿免疫细胞因子及肺功能的影响。方法2014年7月—2015年8月前瞻性收集内蒙古医科大学附属医院儿科收治的支气管哮喘缓解期患儿107例，采用拆信封法分为对照组53例和治疗组54例。两组患儿均于夏季三伏天接受穴位贴敷治疗10次，对照组患儿给予安慰剂穴位贴敷，治疗组患儿给予冬病夏治穴位贴敷。比较两组患儿首次贴敷治疗前及末次贴敷治疗后免疫细胞因子〔核转录因子κB（NF-κB）、白介素4（IL-4）、白介素6（IL-6）、白介素8（IL-8）、白介素10（IL-10）及白介素13（IL-13）〕及肺功能指标〔第1秒用力呼气容积（FEV1）和呼气峰值流速（PEF）〕。结果两组患儿首次贴敷治疗前血清NF-κB、IL-4、IL-6、IL-8、IL-10、IL-13水平比较，差异均无统计学意义（ P ﹥0.05）；治疗组患儿末次贴敷治疗后血清NF-κB、IL-4、IL-6、IL-8、IL-13水平低于对照组，血清 IL-10水平高于对照组（P ﹤0.05）。两组患儿首次贴敷治疗前 FEV1和PEF 比较，差异无统计学意义（P ﹥0.05）；治疗组患儿末次贴敷治疗后 FEV1和 PEF 高于对照组（P ﹤0.05）。结论冬病夏治穴位贴敷疗法能有效调节支气管哮喘缓解期患儿免疫细胞因子水平，改善患儿肺功能。