Objective To investigate the preventive application effect of amiodarone in pre-hospital emergency of acute myocardial infarction. Methods A total of 100 acute myocardial infarction patients undergoing pre-hospital emergency were selected in Beijing Emergency Center from January 2015 to January 2017, and they were divided into control group and observation group, each of 50 cases. Patients in control group received lidocaine in pre-hospital emergency, while patients in observation group received amiodarone. Absolute value of difference value of respiratory rate, heart rate, oxyhemoglobin saturation and blood pressure before treatment and in transit, times of defibrillation and hospital stays were compared between the two groups, incidence of adverse reactions, successful rescue results, incidence of arrhythmia and sudden death were recorded. Results Absolute value of difference value of respiratory rate, heart rate, DBP and SBP before treatment and in transit in observation group were statistically significantly higher than those in control group, while absolute value of difference value of oxyhemoglobin saturation before treatment and in transit in observation group was statistically significantly lower than that in control group (P<0.05). Times of defibrillation in observation group was statistically significantly less than that in control group, meanwhile hospital stays in observation group was statistically significantly shorter than that in control group(P<0.05). Incidence of adverse reactions of observation group was statistically significantly lower than that in control group(P<0.05). Rescue success rate in observation group was statistically significantly higher than that in control group, while incidence of arrhythmia and sudden death in observation group was statistically significantly lower than that in control group, respectively(P<0.05). Conclusion Amiodarone has good preventive application effect in pre-hospital emergency of acute myocardial infarction, can effectively relieve the clinical symptoms, reduce the times of defibrillation, risk of arrhythmia and sudden death, shorten the hospital stays, improve the rescue success rate, with relatively high safety.%目的 探讨胺碘酮在急性心肌梗死院前急救中的预防性应用效果.方法 选取2015年1月—2017年1月北京急救中心收治的行院前急救的急性心肌梗死患者100例,采用随机数字表法分为对照组与观察组,每组50例.对照组患者院前急救中予以利多卡因治疗,观察组患者予以胺碘酮治疗.比较两组患者治疗前与运送途中呼吸频率、心率、血氧饱和度、血压差值的绝对值及除颤次数、住院时间,并记录两组患者不良反应发生情况、抢救成功情况、心律失常发生情况、猝死情况.结果 观察组患者治疗前与运送途中呼吸频率、心率、舒张压、收缩压差值的绝对值高于对照组,血氧饱和度差值的绝对值低于对照组(P<0.05).观察组患者除颤次数少于对照组,住院时间短于对照组(P<0.05).观察组患者不良反应发生率低于对照组(P<0.05).观察组患者抢救成功率高于对照组,心律失常发生率、猝死率低于对照组(P<0.05).结论 院前急救中预防性应用胺碘酮可有效改善急性心肌梗死患者临床症状,减少患者除颤次数,缩短患者住院时间,提高患者抢救成功率,降低心律失常和猝死发生风险,且安全性较高.
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