目的 观察老年2型糖尿病(T2DM)合并大血管病变患者的血液流变学特点. 方法 选取60例老年T2DM患者,根据是否合并大血管病变分为2组,未合并大血管病变者为A组(n=30),合并有大血管病变者为B组(n＝30).检测所有患者血压、血糖、血脂及血液流变学等相关指标并进行比较,同时选取45例老年健康体检者作为对照组. 结果 A组和B组患者血压、空腹血糖、空腹胰岛素、总胆固醇、三酰甘油和低密度脂蛋白胆固醇水平均高于对照组,差异有统计学意义(P ＜0.05或P＜0.01),A组与B组间比较亦有显著性差异(P＜0.05).B组患者全血黏度和纤维蛋白原水平及血小板聚集率与A组比较差异有统计学意义(P＜0.05或P＜0.01). 结论 T2DM合并大血管病变患者存在着明显的血液流变学改变,提示血液流变学改变可能参与了T2DM大血管病变的形成和发展.%Objective To observe the characteristics of hemorheology in the elderly patients with type 2 diabetes (T2DM) combined with macroangiopathy. Methods Sixty T2DM patients aged over 60 were selected and divided into two groups, non-macroangiopathy group (group A, n=30)and combined with macroangiopathy group (group B, re = 30). 45 elderly healthy person were chosen as control group. The levels of blood pressure, plasma glucose,lipid and the index of hemorheology in three groups were detected and compared. Results The levels of blood pressure, fasting plasma glucose , fasting insulin, total cholesterol, triglyceride and low density lipoprotein cholesterol in group A and group B were significantly higher than those in control group(P <0. 05 or P <0. 01) ,and there was significant difference between group A and group B(P <0. 05). The levels of whole blood viscosity, fibrinogen and the platelet aggregation rate in group B were higher than those in group A ( P < 0. 05 or P < 0. 01) . Conclusions The elderly patients with T2DM combined with macroangiopathy have obvious changes of hemorheology, which may play a role in the formation and development of macroangiopathy.
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