老年糖耐量异常患者的认知功能评估

摘要

Objective To investigate the cognitive function in the elderly patients with impaired glucose tolerance ( IGT) . Methods Minimum mental state examination( MMSE) , montreal cognitive assessment( MoCA) scales and P300 detection were used in 42 cases of elderly IGT patients and 50 cases of healthy person. Results The MoCA scores of ag⁃ing IGT patients were significantly lower than those of control group in verbal, attention, delayed recall dimension and total scores( P<0�01) . MMSE score showed no statistical differences between two groups. P300 showed that whether target stim⁃ulus or non⁃target stimulus induced a low, flat wave, and showed significant differences between the two groups. Conclu⁃sions The elderly IGT patients show cognitive impairment. Combination of MoCA scales and P300 test can improve the di⁃agnosis of preclinical cognitive impairment.%目的探讨老年糖耐量异常患者认知功能损害情况。方法对42例老年糖耐量异常患者及50例正常对照组进行简易精神状态量表（ MMSE）、蒙特利尔认知功能评估量表（ MoCA）以及P300检测。结果老年糖耐量异常患者MoCA中语言、注意、延迟回忆得分及总分均较对照组显著下降，差异有统计学意义（ P＜0�01）。MMSE评分亦有下降趋势，但差异无统计学意义。 P300结果显示无论是靶刺激还是非靶刺激，老年糖耐量异常组诱发出的波明显低平及后移，与对照组比较，差异有统计学意义（ P＜0�01）。结论老年糖耐量异常患者存在认知功能损害，联合MoCA量表评估及P300检测有助于老年糖耐量异常患者早期认知功能损害的诊断，有助于临床医师早期发现及干预。