二氧化硅负载硫酸氢钠催化合成乙酰水杨酸

摘要

The synthesis of acetyl salicylic acid with salicylic acid and acetic anhydride as reactants and sodium bisulfate as catalys supported by silica was studied.The factors influencing its catalytic performance were investigated and optimized , including reaction time, reaction temperature, the amount of catalyst.When the amount of salicylic acid was 7.0 g and the amount of acetic anhydride was 11.0 g,the optimum reaction conditions were as follows: the amount of catalyst was 0.6 g;the reaction time was 50 min , the reaction temperature was 80℃.The yield of acetyl salicylic acid was 80.1%.The catalyst could be recycled and used for 3 times.The process would improve the production of acetyl salicylic acid.%研究了以二氧化硅负载硫酸氢钠为催化剂，水杨酸和乙酸酐为原料合成乙酰水杨酸的工艺。考察了催化剂用量、反应时间、反应温度的影响。当固定水杨酸为7.0 g，乙酸酐为11.0 g时，乙酰水杨酸的优化合成条件为：催化剂用量0.6 g，反应时间为50 min，反应温度为80℃。在此条件下，乙酰水杨酸产率为80.1%。催化剂能够重复使用3次。该工艺将改善乙酰水杨酸的生产。