革叶猕猴桃果实不同提取部位抗心肌缺血作用的比较研究

摘要

4 extraction from the fruits of Actinidia rubricaulis var. coriacea were tested for anti-myocardial infarction activities at 3 levels on coronary artery-ligated model rats, isolated guinea-pig hearts and cultured myocardial sheets of mice. All the 4 extractions showed obvious pharmacological effects by decreasing the area of myocardial infraction of the model rats, increasing the amount of blood stream of the isolated guinea-pig hearts and reducing the beating rate and amplitude of cultured myocardial sheets of mice. The chloroform extraction exhibited the highest activities.%目的：比较革叶猕猴桃果实不同提取部位的抗心肌缺血作用。方法：采用冠状动脉结扎致大鼠急性心肌缺血模型，观察革叶猕猴桃果实70%乙醇提取物、正己烷部位、氯仿部位及正丁醇部位对急性心肌梗塞范围的影响，同时观察上述部位对豚鼠离体心脏冠脉流量及小鼠胚胎心肌培养细胞功能的影响。结果：革叶猕猴桃果实不同提取部位均具有抗心肌缺血活性，能降低冠状动脉结扎致心肌梗塞模型大鼠的梗塞范围；增加离体心脏冠脉血流量；降低离体心肌细胞的心率和心肌收缩力，以氯仿部位作用最为明显。