前列地尔治疗呼吸机相关性肺损伤患者的临床研究

摘要

Objective: To observe the effect of alprostadil in the treatment of ventilator induced lung injury (VILI). Methods: A total of 79 patients with ventilator induced lung injury were selected and randomly divided into treatment group (n=40) and control group (n=39). On the basis of treatment of the primary disease, the patients of the treatment group were intravenously pumped with alprostadil 10 μg, twice per day for 7 d. Curative effects, respiratory function parameters and inflammatory factors were observed to evaluate the effects of the 2 groups. Results: The parameters of the 2 groups before treatment had no difference. After 7 days treatment, the treatment group was significantly better than the control group in the parameters of the total effective rate, oxygenation index, spiro-index, APACHEⅡ scores, TNF-α, IL-1β, IL-6 and IL-8. Conclution:Alprostadil significantly improves the clinical conditions of patients with ventilator induced lung injury.%目的：探讨前列地尔治疗呼吸机相关性肺损伤的临床疗效。方法：选择79例呼吸机相关性肺损伤患者，随机分为前列地尔治疗组（n=40）和对照组（n=39），两组患者均在常规积极治疗原发病的基础上采用肺保护性机械通气，治疗组在常规治疗基础上静脉泵注前列地尔10μg，2次/d，共治疗7天。观察两组的临床疗效，呼吸功能指标及炎性因子水平的变化。结果：治疗组与对照组在治疗前各项指标无差异。治疗后治疗组在总有效率、氧合指数、呼吸指数、APACHEⅡ评分、TNF-α、IL-1β、IL-6、IL-8等指标的检测上均显著优于对照组。结论：前列地尔可显著改善机械通气患者呼吸机相关性肺损伤的临床状况。