胃酸相关疾病治疗新药富马酸沃诺拉赞

摘要

富马酸沃诺拉赞为钾离子竞争性酸阻滞剂，是一种新型的可逆性质子泵抑制剂，用于治疗和预防胃酸相关疾病。本文对富马酸沃诺拉赞的作用机制、药效学、药代动力学、药物相互作用、临床评价和安全性等进行综述。%Vonoprazan fumarate is an orally bioavailable potassium-competitive acid blocker (P-CAB), which inhibits gastric H+, K+-ATPase in a reversible manner. Vonoprazan fumarate is developed by Takeda for the treatment and prevention of acid-related diseases. This article summarizes the mechanism, pharmacodynamics, pharmacokinetics, drug interaction, clinical evaluation and safety of vonoprazan fumarate.